Prior to the availability of the pure levothyroxine, desiccated animal thyroid extract was the only treatment for hypothyroidism and some individuals still prefer dessicated thyroid extract as a more “natural” thyroid hormone. NP Thyroid ® (thyroid tablets, USP) is a prescription medicine that is used to treat a condition called hypothyroidism from any cause, except for cases of temporary hypothyroidism, which is usually associated with an inflammation of the thyroid (thyroiditis). Of course, extensive branding and marketing plays a role here. While levothyroxine is a synthetic version, bio-identical to T4 produced in our body, NDT is derived from pigs, purified, and is not bio-identical to hormones produced by the human thyroid gland. 2009;9:132. doi:10.1186/1471-2458-9-132. They contain both tetraiodothyronine sodium (T4 levothyroxine) and triiodothyronine sodium (T3 liothyronine) providing 38 mcg levothyroxine (T4) and 9 mcg liothyronine … Natural thyroid contains both T3 (triiodothyronine) and T4 (thyroxine) as well as calcitonin and other elements found in the thyroid gland. One reason why doctors are more inclined to trust levothyroxine is because it has undergone extensive clinical testing for the treatment of hypothyroidism and it has been approved by the FDA. In one of the only studies comparing desiccated thyroid extract to levothyroxine, doctors from Walter Reed National Military Medical Center in Bethesda, MD, compared the results when 70 people with hypothyroidism took each medication for 16 weeks. Learn My Easy Anti-Inflammatory Diet, Things to Consider Before Choosing a Multivitamin. Once ingested Synthroid is converted by the body into T3, the active thyroid … For example, one study found that coffee should be added to the list of things that affect intestinal absorption of T4. Levothyroxine Sodium 105 mg (15 mg + 90 mg) 15 mg (1/4 grain) Desiccated Porcine Thyroid Extract 30 mg (1/2 grain) 90 mg (1.5 grain) 60 mg (1 grain) 16.25 mg 32.5 mg 65 mg 97.5 mg 130 mg 25 mcg 50 mcg 100 mcg 150 mcg 45 mg (15 mg + 30 mg) 75 mcg 88 mcg 75 mg (15 mg + 60 mg) 125 mcg 137 mcg T4/T3 112 mcg Armour ® Thyroid … Levothyroxine, as you can conclude based on its name, contains T4 only while natural desiccated thyroid medication contains both T3 and T4. Home » Patients Portal » Clinical Thyroidology for the Public » Vol 6 Issue 8 » Vol 6 Issue 8 p.3, CLINICAL THYROIDOLOGY FOR PATIENTS This medicine can improve symptoms of thyroid deficiency such as slow speech, lack of energy, weight gain, hair loss, dry skin, and feeling cold. It also brought a new era where levothyroxine became more commonly used while NDT drugs were pushed aside. Hypothyroidism: a condition where the thyroid gland is underactive and doesn’t produce enough thyroid hormone. Even though the actions of levothyroxine may take a few hours, natural desiccated thyroid works within an hour. Currently desiccated thyroid extract is made from pig thyroids and is available as Armour Thyroid™ and Nature-Throid™. It is impossible not to think that the idea of levothyroxine being the only valid choice for this problem is somehow related to the pharmacological industry itself. The natural thyroid also referred to as a desiccated thyroid is a drug created to improve thyroid hormone production. Both interventions are capable of reducing symptoms of hypothyroidism and are typically well-tolerated. It contains only synthetic T4, which is biologically identical to the T4 produced by the body. I have had the above mentioned issues for a year now even though I have been off NP Thyroid … Synthetic thyroid hormone such as Synthroid and Tirosint only includes thyroxine, also known as T4. NP Thyroid (thyroid tablets, USP) for oral use is a natural preparation derived from porcine thyroid glands. In addition, levothyroxine is on the List of Essential Medicines published by the World Health Organization. In order to determine what type of hormone or medication is best for you, try answering the following questions: Do you have sensitivities to the fillers used in medications? T3 is more biologically active than T4. Research about the safety of NDT use is lacking, which only proves that a lot of things about this medication are simply inaccurate. While it is reasonable to assume that synthetic medications are less desirable than natural counterparts, in this case- natural thyroid hormone replacement is definitely not an ideal solution for the vast majority of people. Dr. Zayed has spent his time between treating patients in the hospital and spreading awareness among the public. From what I have been reading seems kinda low starting dose. If you are already on Armour thyroid and interested in switching to NP thyroid then it probably will not help with weight loss significantly. It aids in … Two different forms of medications are available: natural thyroid and levothyroxine. On the other hand, some professionals opt not to use levothyroxine out of fear it may be linked to long-term adverse effects because it is synthetic. Thyroid 2008 Mar;18(3):293-301. Natural hormone replacement provides both T4 and T3 hormones, and since it is isolated from pig thyroid gland, its dosage is different from that of synthetic T4. The use of levothyroxine came as a step forward and an improvement in the way we treat and manage hypothyroidism. Prior to the availability of the pure levothyroxine, desiccated animal thyroid extract was the only treatment for hypothyroidism. Today, some individuals prefer dessicated thyroid extract as a more “natural” thyroid hormone. Both types of thyroid hormone were able to normalize the abnormal thyroid blood tests. You may be expecting a specific answer, but things aren’t as simple as black or white. It’s easy to claim that the drug isn’t effective and you should move on to the other option, but what about actually proving your claims? How? Hoang TD et al Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: A randomized, double-blind, crossover study. At this point, you are probably wondering about the best option for hypothyroidism: levothyroxine or natural desiccated thyroid. Untreated hypothyroidism is associated with a wide variety of symptoms, many of which are nonspecific. Both drugs serve the same purpose of ensuring sufficient thyroid hormone levels but they have more differences than similarities. Doi: 10.1016/0002-9343(78)90057.8 http://www.sciencedirect.com/science/article/pii/0002934378900578, Tagged: thyroid function, Thyroid Health, thyroid weight gain, © Women's Wellness Collaborative LLC, Chandler, AZ, USA, Addressing Hashimoto's and Graves' Disease with Dr. Eric Osansky, Natural Thyroid vs Levothyroxine by Dr. Ahmed Zayed, https://www.endocrinesociety.org.au/ESA_Position_Statement_%20Thyroid-Extract.pdf, http://jamanetwork.com/journals/jama/article-abstract/441500, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683823/, http://www.who.int/medicines/publications/essentialmedicines/EML_2015_FINAL_amended_NOV2015.pdf?ua=1, https://www.ncbi.nlm.nih.gov/pubmed/18341376?dopt=Citation, https://www.ncbi.nlm.nih.gov/pubmed/23539727, http://www.sciencedirect.com/science/article/pii/0002934378900578, 25 Ways to Effectively Detox the Lymphatic System, Probiotic Guide: a Focus on Keystone Strains, What Should You Eat? Natural thyroid products are available in “grains.” It is estimated that 1 grain of Armour Thyroid (or about 60 mg) is about the same as 88 mcg of levothyroxine. And despite the fact that desiccated thyroid extracts have been used quite frequently before, they have never been subjected to the strict evaluation as levothyroxine. Most controversial statements by doctors about NDT aren’t supported by solid evidence. Both natural thyroid and levothyroxine have similar side effects. J Clin Endo- crinol Metab 2013;98:1982-90. Never change anything in thyroid treatment just because you feel like it without consulting your doctor. Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism. The researchers report that 49% of the patients preferred desiccated thyroid extract, 19% preferred levothyroxine and 23% had no preference. Mary Shomon on Natural Thyroid vs Synthetic. The primary difference is in the nature of these medications. When looking at the differences between levothyroxine and natural thyroid, it is important to mention that brand names like Armour Thyroid and Synthroid have a different relationship with the FDA. The drug companies making levothyroxine have become primary funding sources for thyroid and endocrinology associations, medical school educational programs regarding thyroid … LEVOTHYROXINE and LIOTHYRONINE (lye oh THYE roe neen) Porcine, also known as Dessicated Thyroid, is a combination of 2 thyroid hormones. Ever since levothyroxine came into use and NDTs were neglected, generations of young doctors were trained to understand the synthetic drug and its efficacy. Although desiccated thyroid extract is not widely used, this study showed that many patients preferred this option as compared with levothyroxine. The drug can also induce thyrotoxic symptoms. Treatment options for underactive thyroid gland focus on intake of medications that stimulate the production of hormones. The drug was first developed back in the 1900s and the earliest form came from the thyroid gland of cows, but later researchers focused on pigs. For example chest pain/discomfort, changes in the menstrual cycle, fast or irregular heartbeat, fever, tremors, irritability, sweating, vomiting, and nausea, just to name a few. Further research is needed on this topic to confirm which patients this might benefit the most form desiccated thyroid extract therapy. A synthetic version of hormone replacement therapy has been available since 1927 when British chemists Barger and Harington synthesized thyroxine for the very first time. To most doctors, this is entirely justified. I was previously on 112 mcg Synthroid. SUMMARY OF THE STUDY But of course this is a subject to discuss with your healthcare provider. Doi: 10.1089/thy.2007.0222 https://www.ncbi.nlm.nih.gov/pubmed/18341376?dopt=Citation, [1] Hoang TD, Olsen CH, Mai VQ, et al. Also, some doctors believe that prescribing natural desiccated thyroid is difficult because there is a great deal of unavailability from batch to batch which can lead to TSH fluctuations. For example, Levothyroxine, Levothroid, Unithroid, and Tirosint. While we are led to believe that only levothyroxine is good for our thyroid, the truth is that there is no evidence to support claims about NDT being more dangerous. Don’t forget that these drugs have the primary function to ensure sufficient levels of thyroid hormones. Desiccated thyroid extract compared to levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. Epub March 28, 2013. This study was performed to compare levothyroxine to desiccated thyroid … Table of Contents | PDF File for Saving and Printing, HYPOTHYROIDISM 6 no. Treatment requires taking thyroid hormone pills. It is more useful to take both of these drugs in the morning due to the energy boost they provide. Taking your thyroid hormone replacement medication (most commonly, levothyroxine) first thing in the morning with water and waiting at least an hour before eating breakfast or drinking coffee is what has been traditionally recommended for years by thyroid … JAMA June 1915;LXIV(25):2042-2043. Originally I was treated with Synthroid, then switched to levothyroxine at 125 mcg. Neither natural thyroid nor levothyroxine serve for prevention of thyroid cancer. Morning Levothyroxine . Bianco’s view is particularly interesting because he co-chaired the task force that prepared ATA’s latest hypothyroidism guidelines in 2014, which concluded that LT4 should remain the standard in treatment for hypothyroidism: “We found no consistently strong evidence for the superiority of alternative preparations (e.g., levothyroxine-liothyronine combination therapy, or thyroid extract therapy, or others) over monotherap… Neither levothyroxine nor natural thyroid correct autoimmune dysfunction. WHAT ARE THE IMPLICATIONS OF THIS STUDY? [1] Thyroid Basics, Nature Throid, June 2017, [1] Ebeling PR, ESA position statement on desiccated thyroid or thyroid extract https://www.endocrinesociety.org.au/ESA_Position_Statement_%20Thyroid-Extract.pdf, [1] Thyroid Advisor, Synthroid/Levothyroxine Complete Overview – History, Usage, Dosage, Interactions, Side Effects July 2017, https://thyroidadvisor.com/synthroid-and-levothyroxine-complete-overview/, [1] Kendall EC. The answer is that it really depends. The American Journal of Medicine February 1978, vol. Inflammation and higher testosterone or estrogen can affect the working of the thyroid hormone drug you're taking.
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